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Bronchiolitis obliterans (BO), also called obliterative bronchiolitis (OB) and constrictive bronchiolitis (CB), is a rare and life-threatening form of non-reversible obstructive lung disease in which the bronchioles (small airway branches) are compressed and narrowed by fibrosis (scar tissue) and/or inflammation.〔(Merriam-Webster Medical Dictionary > bronchiolitis obliterans ) Retrieved on August, 2010〕 Bronchiolitis obliterans is also sometimes used to refer to a particularly severe form of pediatric bronchiolitis caused by adenovirus. ''Bronchiolitis'' means inflammation of the bronchioles and ''obliterans'' refers to the inflammation or fibrosis of the bronchioles partially or completely obliterating the airways. Bronchiolitis obliterans has always been thought to be irreversible and progressive,〔(【引用サイトリンク】title=Dorlands Medical Dictionary:bronchiolitis fibrosa obliterans )〕 but a new study that uses inhaled cyclosporine has been shown to increase the FEV1% while patients are able to decrease their systemic steroid doses.〔http://www.bbmt.org/article/S1083-8791(14)01260-9/pdf〕 ==Signs and symptoms== Bronchiolitis obliterans is a lung disease characterized by fixed airway obstruction. Inflammation and scarring occur in the airways of the lung, resulting in severe shortness of breath and dry cough. FEV1 (forced expiratory volume in 1 second) should be above 80% of predicted values to be considered normal. Bronchiolitis obliterans reduces this to 16% to 21%. Symptoms include: * dry cough * shortness of breath * wheezing The symptoms can start gradually, or severe symptoms can occur suddenly.〔http://www.morethanacold.co.uk/about-bronchiolitis/bronchiolitis-symptoms.aspx〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「bronchiolitis obliterans」の詳細全文を読む スポンサード リンク
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